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KMID : 0829220090330060327
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Korean Journal of Oral and Maxillofacial Pathology
2009 Volume.33 No. 6 p.327 ~ p.336
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Correlation Between the Overexpression of Cyclooxygenase 2 by Cytoplasmic HuR and Microvessel Density in Human Head and NeckS quamous Cell Carcinoma
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Han Hye-Suk
Cho Sung-Dae
Shim Jung-Hyun
Shin Ji-Ae
Cho Nam-Pyo
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Abstract
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The human embryonic-lethal abnormal vision-like protein, HuR, stabilizes mRNA containing adenine- and uridine- rich elements in their 3’untranslated region. Because cyclooxygenase-2 (COX-2) mRNA is a cellular transcript that contains an adenine- and uridine-rich element, it can be regulated by the HuR protein. In this study, we examined the relationship between COX-2, HuR, MVD, and the clinicopathological parameters. Nineteen out of 43 cases of HNSCC showed high level of COX-2expression, and 68% of these patients showed high COX-2 immuno-reactivity indicating the strong expression of the cytoplasmic HuR protein. Also, MVD expression in the cases with high COX-2 expression was higher than in the cases with low COX-2 expression. These results suggest a strong correlation between the overexpression of cytoplasmic HuR and COX-2 expression in HNSCC, and that COX-2 is associated with MVD in HNSCC. In conclusion, COX-2 regulated by cytoplasmic HuR may be a good tumor angiogenic factor in HNSCC.
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KEYWORD
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HNSCC, HuR, COX-2, MVD, Angiogenesis
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